A) Promoting apoptosis B) Inhibiting protein synthesis C) Promoting survival and growth D) Reducing cellular metabolism
A) Ras B) PTEN C) Grb2 D) PIP3
A) Lipid kinase B) Serine/threonine kinase C) Tyrosine kinase D) Histidine kinase
A) GAB B) Sos1 C) PTEN D) IRS
A) Regulatory p85 and catalytic p110 subunits B) Regulatory p110 and catalytic p85 subunits C) Two identical catalytic subunits D) Single catalytic subunit only
A) Via its lipid-binding domain B) Via its kinase domain C) Via its G protein-binding domain D) Via its SH2 domain
A) PTEN B) Ras C) Sos1 D) Grb2
A) Akt B) Ras-GTP C) PIP3 D) PTEN
A) Cystic fibrosis and asthma B) Hypertension and arthritis C) Cancer and type 2 diabetes D) Anemia and malaria
A) 100 B) 10 C) 500 D) 1000
A) Via G-protein beta-gamma dimers or Ras B) Via inhibition of Grb2 C) Via recruitment of PTEN D) Via direct phosphorylation of p85
A) Dephosphorylation of p85 B) Binding of an extracellular ligand C) Loss of PTEN function D) Binding of intracellular PIP3
A) Lipid cleavage B) Receptor degradation C) Nuclear translocation D) Receptor dimerization
A) Mitochondrial matrix B) Plasma membrane C) Nuclear envelope D) Endoplasmic reticulum
A) Akt B) PDK1 C) PI3K D) mTORC2
A) PI B) PI(3,4,5)P3 C) PI(3,4)P2 D) PI(3)P
A) Cytosol B) Plasma membrane C) Endoplasmic reticulum D) Nucleus
A) Ser473 B) Thr473 C) Ser308 D) Thr308
A) DNA-PK B) mTORC2 C) PDK1 D) ILK
A) Translocation to the nucleus B) Binding to inhibitory proteins C) Dephosphorylation by phosphatases D) Degradation by proteasomes
A) They decrease B) They convert to PI C) They remain stable D) They increase
A) CAMKK B) PDK1 C) mTORC2 D) ILK
A) Calcium depletion B) Heat shock C) DNA damage D) PI3K activity
A) PP2A B) SHIP C) PHLPP D) PTEN
A) FoxO B) S6K1 C) IRS-1 D) NEDD4-1
A) PHLPP B) PP2A C) SHIP D) PTEN
A) PP2A B) CTMP C) SHIP D) PHLPP
A) It directly phosphorylates PTEN to increase its activity B) It up-regulates the E3 ligase NEDD4-1 C) It promotes the stability of PTEN mRNA D) It activates the transcription of PTEN
A) PTEN B) mTORC1 C) PP2A D) Akt |