- 1. What kind of antigens do NKT cells recognize?
A) Peptides
B) Lipids and glycolipids
C) Nucleic acids
D) Polysaccharides
- 2. Which molecule presents antigens to NKT cells?
A) CD161
B) MHC class I
C) CD1d
D) MHC class II
- 3. What percentage of peripheral blood T cells are NKT cells?
A) Approximately 25%
B) Approximately 10%
C) Approximately 5%
D) Approximately 1%
- 4. What is the original marker used to identify NKT cells in mice?
A) CD8
B) NK1.1
C) CD4
D) CD56
- 5. Which microorganism is cited as being recognized by NKT cells due to its glycolipids?
A) Streptococcus
B) Candida
C) Mycobacterium
D) Influenza virus
- 6. Which transcription factor is critical for the development of iNKT cells?
A) Rorc
B) PLZF
C) Gata3
D) Runx3
- 7. Where do NKT cells differentiate into effector cells?
A) Spleen
B) Thymus
C) Bone marrow
D) Lymph nodes
- 8. What interaction is required for the costimulation of NKT cells during differentiation?
A) CD1d-TCR interaction
B) MHC-TCR interaction
C) NK1.1-CD1d interaction
D) SLAM-SLAM interaction
- 9. What is the result of elevated TCR signaling in NKT thymic precursors?
A) Apoptosis
B) Upregulation of Egr2
C) Immediate cytokine release
D) Downregulation of PLZF
- 10. Which cytokine is mentioned as being related to PLZF-regulated genes?
A) IL-2
B) IL-10
C) TNF-alpha
D) IL-4
- 11. Which lipid molecule was previously thought to be important for NKT development but lacks a synthesis enzyme in humans?
A) Cholesterol
B) iGb3
C) Ceramide
D) Sphingomyelin
- 12. In the lineage differentiation model, which subsets can a thymic T cell develop into before stage zero?
A) CD4+, CD8+, and double negative
B) NKT1, NKT2, and NKT17
C) Type 1, Type 2, and Type 3
D) NK1.1+, NK1.1-, and CD56+
- 13. NKT cells co-express an alpha-beta T-cell receptor with markers typically found on what other cell type?
A) Natural killer cells
B) Dendritic cells
C) Macrophages
D) B cells
- 14. What is a distinguishing feature of 'type 1' NKT cells compared to conventional T cells?
A) Lack of TCR expression
B) Absence of CD1d binding
C) Limited TCR diversity
D) High MHC class II expression
- 15. Besides IFN-gamma and IL-4, which other cytokine production is associated with PLZF?
A) IL-6
B) IL-1
C) IL-3
D) IL-12
|