Central dogma of molecular biology - Quiz
Central dogma of molecular biology
  • 1. What is RNA replication?
A) The translation of RNA into protein
B) The synthesis of DNA from RNA
C) The degradation of RNA molecules
D) The copying of one RNA to another
  • 2. What are the enzymes that copy RNA to new RNA called?
A) Reverse transcriptases
B) Ribosomal peptide synthetases
C) RNA-dependent RNA polymerases
D) DNA-dependent RNA polymerases
  • 3. Where are RNA-dependent RNA polymerases also found, besides viruses?
A) Only in prions
B) In many eukaryotes
C) Exclusively in bacterial plasmids
D) Only in prokaryotes
  • 4. What role do RNA-dependent RNA polymerases play in eukaryotes?
A) DNA replication
B) Intein excision
C) RNA silencing
D) Nonribosomal peptide synthesis
  • 5. What is RNA editing?
A) The destruction of messenger RNA
B) An RNA sequence being altered by a protein complex and a guide RNA
C) The creation of DNA from a protein template
D) The conversion of proteins into RNA
  • 6. What does the central dogma of molecular biology state about sequential information once it passes from nucleic acid to protein?
A) It cannot flow back from protein to nucleic acid
B) It is immediately destroyed by enzymes
C) It must be converted into carbohydrates
D) It can easily flow back to nucleic acid
  • 7. What is post-translational modification?
A) The direct translation of proteins back into DNA
B) The synthesis of RNA without a DNA template
C) Editing of protein amino-acid sequences by appropriate enzymes after translation
D) The replication of prions in host cells
  • 8. Does post-translational modification involve proteins transferring information to nucleic acid?
A) No
B) Yes
C) Only in eukaryotes
D) Only in viruses
  • 9. What synthesizes nonribosomal peptides?
A) Homing endonucleases
B) Nonribosomal peptide synthetases
C) RNA-dependent RNA polymerases
D) Ribosomes
  • 10. What structural features often differentiate nonribosomal peptides from ribosome-synthesized proteins?
A) Cyclic or branched structures and non-proteinogenic amino acids
B) Lack of any peptide bonds
C) Double-stranded nucleic acid backbones
D) Linear structures and standard amino acids only
  • 11. What is an example of nonribosomal peptides?
A) Prion proteins
B) All ribosomal enzymes
C) Most DNA polymerases
D) Some of the antibiotics
  • 12. What is an intein?
A) A parasitic segment of a protein that is able to excise itself
B) A non-proteinogenic amino acid
C) A guide RNA used in RNA editing
D) A type of virus that replicates RNA
  • 13. What does an intein do as amino acid chains emerge from the ribosome?
A) Replicates the ribosomal RNA
B) Destroys the entire protein backbone
C) Converts the protein into a nucleic acid
D) Excises itself from the chain and rejoins the remaining portions
  • 14. What domain do most inteins contain?
A) A prion conformation domain
B) An RNA silencing domain
C) A nonribosomal peptide synthetase domain
D) A homing endonuclease or HEG domain
  • 15. What does the HEG domain initiate upon contacting an intein-free copy of the parent gene?
A) The synthesis of nonribosomal antibiotics
B) The DNA double-stranded break repair mechanism
C) The reversal of the central dogma
D) The immediate degradation of the host cell
  • 16. What are prions?
A) Enzymes that edit RNA sequences
B) Proteins of particular amino acid sequences in particular conformations
C) Small RNA-dependent polymerases found in eukaryotes
D) Nonribosomal peptide synthetases
  • 17. How do prions propagate themselves in host cells?
A) By translating RNA directly into new prions
B) By excising themselves from protein backbones
C) By making conformational changes in other molecules of protein with the same amino acid sequence
D) By copying their own nucleic acid sequences
  • 18. What is the information flow in some types of prion in fungi?
A) RNA → DNA → Protein
B) Nucleic acid → Protein → Nucleic acid
C) Protein → Nucleic acid
D) Protein → Protein
  • 19. Which scientists argued that prion-mediated inheritance violates the central dogma?
A) Alain E. Bussard and Eugene Koonin
B) Not mentioned in the text
C) Watson and Crick
D) Rosalind Ridley
  • 20. What did Rosalind Ridley write regarding the prion hypothesis and the central dogma?
A) Prions prove that information flows backward from proteins to DNA
B) Proteins are capable of manufacturing nucleic acid sequences
C) The prion hypothesis completely destroys the central dogma by proving protein replication
D) The prion hypothesis is not heretical to the central dogma because it does not claim that proteins replicate
  • 21. Who first stated the central dogma in 1957?
A) Gregor Mendel
B) Rosalind Franklin
C) James Watson
D) Francis Crick
  • 22. In what year was Francis Crick's original statement of the central dogma published?
A) 1970
B) 1965
C) 1955
D) 1958
  • 23. In what year was Crick's Nature paper re-stating the central dogma published?
A) 1980
B) 1958
C) 1965
D) 1970
  • 24. Who published the popular but incorrect second version of the central dogma?
A) James Watson
B) Gregor Mendel
C) Francis Crick
D) Watson and Crick
  • 25. In what year was James Watson's first edition of The Molecular Biology of the Gene published?
A) 1975
B) 1970
C) 1958
D) 1965
  • 26. Between Crick's and Watson's versions of the central dogma, which one remains valid today?
A) Watson's version
B) Both are equally valid
C) Neither remains valid
D) Crick's original version
  • 27. What type of polymers are DNA, RNA, and polypeptides?
A) Circular lipids
B) Branched homopolymers
C) Cross-linked polysaccharides
D) Linear heteropolymers
  • 28. In linear heteropolymers, each monomer is connected to at most how many other monomers?
A) One
B) Four
C) Two
D) Three
  • 29. How are the transfers of information from one biopolymer to another described?
A) Random and spontaneous
B) Faithful, deterministic transfers
C) Chaotic and reversible
D) Inconsistent and unstable
  • 30. In groups of how many are proteins encoded?
A) One
B) Two
C) Three
D) Four
  • 31. What are groups of three bases encoding proteins called?
A) Codons
B) Templates
C) Monomers
D) Polymers
  • 32. Which lifeforms or structures are specifically noted as using different translations from the standard codon table?
A) Human mitochondria
B) Somatic cells
C) Plant chloroplasts
D) Bacterial ribosomes
  • 33. What complex group of proteins performs DNA replication?
A) Ribosomes
B) Transcription factors
C) The replisome
D) RNA polymerase
  • 34. During DNA replication, information is copied from the parent strand to which strand?
A) Polypeptide chain
B) Pre-mRNA transcript
C) Template mRNA strand
D) Complementary daughter strand
  • 35. What is the process by which information in a section of DNA is replicated into mRNA called?
A) Transcription
B) Splicing
C) Translation
D) Replication
  • 36. What is the primary transcript called in eukaryotic cells?
A) Polypeptide
B) Pre-mRNA
C) Mature mRNA
D) Complementary DNA
  • 37. What process follows the addition of the 5' cap and poly-A tail to pre-mRNA?
A) Splicing
B) Replication
C) Translation
D) Duplication
  • 38. Where does translation occur for mature mRNA?
A) At the Golgi apparatus
B) Inside the cell nucleus
C) At a ribosome
D) Within the endoplasmic reticulum
  • 39. Where is the site of translation in eukaryotic cells?
A) The cell nucleus
B) The cytoplasm
C) The nucleolus
D) The nuclear pore
  • 40. What is the usual initiator codon that begins translation?
A) UGA
B) AUG
C) UAG
D) UAA
  • 41. What does the acronym AUG stand for in the text?
A) Adenine-thymine-guanine
B) Adenine-uracil-cytosine
C) Alanine-uracil-glycine
D) Adenine-uracil-guanine
  • 42. Which of the following is a stop codon that ends translation?
A) UAA
B) GUA
C) UCA
D) AUG
  • 43. Which triplet can also serve as a stop codon?
A) MET
B) UGA
C) ACC
D) AUG
  • 44. Which of the following is listed in the text as a stop codon?
A) ACU
B) AUG
C) GUU
D) UAG
  • 45. What are the inside 'discarded' sections called when some proteins excise internal segments?
A) Retroviruses
B) Cofactors
C) Codons
D) Inteins
  • 46. What is the family of enzymes involved in reverse transcription called?
A) Initiation factors
B) Chaperone proteins
C) Elongation factors
D) Reverse Transcriptase
  • 47. Who pointed out to Crick that he did not understand the correct use of the word dogma?
A) Albert Einstein
B) Horace Freeland Judson
C) Jacques Monod
D) August Weismann
  • 48. How did Crick view religious beliefs?
A) As absolute truths
B) As experimentally proven
C) As central dogma
D) Without foundation
  • 49. What kind of support did Crick's central dogma have at the time he named it?
A) Universal acceptance
B) Extensive experimental support
C) Little direct experimental support
D) No theoretical backing
  • 50. Who recorded Crick's explanation of the word dogma in 'The Eighth Day of Creation'?
A) August Weismann
B) Francis Crick
C) Jacques Monod
D) Horace Freeland Judson
  • 51. How did Crick describe the word dogma in his interview with Judson?
A) A catch phrase
B) A proven fact
C) A religious law
D) A sacred truth
  • 52. Who proposed the Weismann barrier?
A) August Weismann
B) Horace Freeland Judson
C) Jacques Monod
D) Francis Crick
  • 53. In what year was the Weismann barrier proposed?
A) 1892
B) 1953
C) 1882
D) 1900
  • 54. How are germ cell lineages described in the context of the Weismann barrier?
A) Immortal
B) Temporary
C) Somatic
D) Disposable
  • 55. How are somatic cells described in the context of the Weismann barrier?
A) Permanent
B) Immortal
C) Disposable
D) Germline
  • 56. In what terms was the Weismann barrier's view of life expressed?
A) Religious terms
B) Quantum terms
C) Molecular terms
D) Non-molecular terms
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