Neuropsych Final Practice Exam #1- Chapter 27
  • 1. The brains of schizophrenic patients
A) all of the above
B) have smaller frontal lobes
C) have larger ventricles
D) tend to weight less
E) have thinner hippocampal gyri
  • 2. poor working memory in schizophrenic patients is related to reduced GABA synthesis in GABA neurons in the
A) ventromedial prefrontal cortex
B) amygdala
C) orbitofrontal cortex
D) dorsolateral prefrontal cortex
E) hippocampus
  • 3. Patients with schizophrenia tend to have decreased activation of the _________ lobes during tasks.
A) frontal
B) none of the above
C) parietal
D) occipital
E) temporal
  • 4. The dorsolateral prefrontal cells of schizophrenic patients tend to have _______________________ and ______________________.
A) complex dendritic organization; fewer synapses than normal
B) complex dendritic organization; more synapses than normal
C) simple dendritic organization; fewer synapses than normal
D) simple dendritic organization; more synapses than normal
  • 5. In patients with schizophrenia, the ____________________ of the __________ tend to have haphazard orientation that occurs during embyogenesis and suggests a developmental abnormality. This may be the reason for the abnormalities in structure/function of the _________ cortex.
A) dopamine receptors; basal ganglia; frontal
B) pyramidal neurons; hippocampus; frontal
C) multimodal neurons; amygdala; temporal
D) sensory neurons; primary motor cortex; parietal
  • 6. Research on dopaminergic input from the ______________ to the prefrontal cortex has suggested that abnormal dopamine activity in the frontal lobe could be associated with some symptoms of schizophrenia.
A) tectum
B) basal ganglia
C) cerebellum
D) tegmental area
E) PAG
  • 7. Type I, __________ schizophrenia, is characterized by ___________ symptoms like delusions and hallucinations.
A) chronic; negative
B) acute; negative
C) chronic; positive
D) acute; positive
  • 8. Some suggest that Type I schizophrenia and positive symptoms are related to ___________________. Patients with Type I respond _______ to neuroleptic drugs.
A) a dopaminergic dysfunction; more
B) a dopaminergic dysfunction; less
C) structural abnormalities; more
D) structural abnormalities; less
  • 9. Some suggest that Type II schizophrenia and negative symptoms are related to ___________________. Patients with Type II respond _______ to neuroleptic drugs.
A) a dopaminergic dysfunction; poorly
B) structural abnormalities; poorly
C) a dopaminergic dysfunction; better
D) structural abnormalities; better
  • 10. As many as ____% of patients with schizophrenia display a mixture of Type I and Type II. This may suggest that the Type I and Type II groupings are opposite endpoints on a continuum of biological and behavioral correlates.
A) 50
B) 10
C) 75
D) 30
E) 15
  • 11. In addition to abnormalities in dopaminergic activity, some research suggests that patients with schizophrenia may have abnormalities in ________________activity.
A) serotonin
B) all of the above
C) GABA and glutamate
D) norepinepherine
E) testosterone and estrogen
  • 12. If you give a patient with schizophrenia a stimulant, they would probably have __________ symptoms, like ____________ paranoia.
A) heightened; decreased
B) less; increased
C) less; decreased
D) heightened; increased
  • 13. Which of the following is NOT true?
A) All of the above are true.
B) BDNF is downregulated by stress.
C) BDNF dysfucntion may adverseley affect monoamine systems through the loss of either neurons or synapses.
D) BDNF acts to enhanve the growth and survival or neurons and synapses.
E) BDNF is upregulated by antidepressant medication.
  • 14. In Depression, the deactivation feedback loo of the hypothalamic-adrenal system (which normally begins when cortisol binds to hypoathalamic receptors) produces chronic activation, which is experienced as
A) chronic stress
B) negative affect
C) anhedonia
D) loss of interest
E) sleep difficulty
  • 15. In depressed patients, there is decreased blood flow and metabolism in the ____________________ areas.
A) medial thalamus
B) amygdala
C) dorsolateral and medial prefrontal
D) orbitofrontal
  • 16. In depressed patients, there is increased blood flow and metabolism in the ______________________.
A) amygdala
B) all of the above
C) medial thalamus
D) orbitofrontal regions
  • 17. Severity of depressive symptoms is positively correlated with increases in glucose metabolism in the
A) prefrontal cortex
B) hypothalamus
C) amygdala
D) none of the above
E) hippocampus
  • 18. Increased amygdala activity in depressed patients may be related to increased ________________ activity. Thus, increased activity in the ____________ may be a result of an attempt to modulate/inhibit amygdala activity.
A) orbitofrontal cortex; HPA axis
B) HPA axis; orbitofrontal cortex
C) HPA axis; dorsolateral regions
D) dorsolateral regions; HPA axis
  • 19. Higher ____________ activity appears to reduce depressive symptoms.
A) dorsolateral
B) amygdala
C) HPA axis
D) orbitofrontal
  • 20. Lowered dorsolateral prefrontal activity/blood flow relates to reduced ______________________ in depression.
A) rumination
B) memory and attentional processing
C) emotional processing
D) sleep
  • 21. Some research suggests that patients with depression have abnormal slow-wave sleep and rapid onset of REM sleep.
A) Um...waffles?
B) True
C) I have no idea.
D) False
  • 22. A genetic disorder that results in intellectual deterioration and abnormal movements that get worse with age.
A) Kluver Bucy syndrome
B) Alzheimer's disease
C) Huntington's chorea
D) Tourette's syndrome
E) Dementia
  • 23. All of the following are related to Huntington's chorea except
A) apraxia, aphasia, and agnosias
B) thinning of the cerebral cortex
C) shrinkage of the cerebral cortex
D) atrophied basal ganglia with loss of intrinsic neurons and an imbalance of neurotransmitter symptoms
E) death of GABA and Acetylcholine neurons in the basal ganglia
  • 24. The normal transmitter system is really disrupted in patients with Huntington's chorea when
A) ACh and GABA neurons die in the Substantia Nigra.
B) ACh and GABA neurons die in the Basal Ganglia.
C) all of the above
D) none of the above
E) ACh and GABA neurons die in the cortex.
  • 25. Which of the following are NOT symptoms of Huntington's chorea:
A) problems of recent memory and information processing
B) vocal tics, echolalia, coprolalia, and motor tics
C) inability to sustain muscle contraction or tongue protrusion
D) progressively worse restless involuntary movements
E) reduction of activity and interest
  • 26. Neuropsychological studies show that Huntington patients are impaired in
A) frontal-lobe tests
B) memory tests
C) visual, auditory, and tactile perceptual tests
D) none of the above
E) all of the above
  • 27. The 3 stages of Tourette's Syndrome are
A) 1. multiple tics 2. multiple tics and inarticulate cries 3. articulated words and multiple tics
B) 1. articulated words 2. inarticulate cries 3. multiple tics
C) 1. inarticulate cries 2. articulated words 3. multiple tics
  • 28. Which of the following are NOT true?
A) Tourette's syndrome has a familial/genetic basis.
B) Tourette's syndrome is less common than previously expected.
C) Tourette's syndrome has life long symptoms.
D) Tourette's syndrome does not have neurosis or psychosis.
E) Tourette's syndrome usually begins between 2 and 15 years old
  • 29. Tourette's syndrome has a subcortical origin, with abnormalities in the ______________ system of the _____________.
A) acetylcholine; basal ganglia
B) acetylcholine; cerebellum
C) dopaminergic; basal ganglia
D) dopaminergic; cerebellum
  • 30. Which of the following etiologies is NOT associated with nondegenerative dementia?
A) Neurosyphillis
B) Korsakoff's syndrome
C) Alzheimer's disease
D) AIDS
E) Multiple Sclerosis
  • 31. The most prevalent form of dementia (65%) is
A) Vascular
B) Multiple Sclerosis
C) Korsakoff's
D) Infectious
E) Alzheimer's disease
  • 32. In regard to the neocortex, which areas are most affected by Alzheimer's disease?
A) the primary motor cortex, the parahippocampal formation, and the entorhinal cortex
B) occipital areas, superior temporal suclus, and the somatosensory cortex
C) the blueberries, the apples, and the oranges
D) posterior patietal areas, inferior temporal cortex, and the limbic cortex
  • 33. Which of the following are anatomical correlates of Alzheimer's disease?
A) none of the above
B) increased concentrations of amyloid plaques in the cerebral cortex
C) neurofibrillary tangles in the cerebral cortex and the hippocampus
D) all of the above
E) dendritic arborization related to widespread cortical atrophy
  • 34. In patients with Alzheimer's disease, where is the earliest and most severe degeneration of cells?

    *note: this area is a relay station between the neocortex and the hippocampus and damage to it causes direct memory loss symptoms
A) insula
B) superior temporal sulcus
C) orbitofrontal cortex
D) hypothalamus
E) entorhinal cortex
  • 35. All of the following are possible causes of Alzheimer's disease EXCEPT
A) trace metals
B) abnormal proteins
C) immune reactions
D) watermelon
E) genetics
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