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Phospholipid - Quiz
Contributed by: Peck
  • 1. Which enzyme splits PIP2 into IP3 and DAG?
A) Gq protein
B) Phospholipase C
C) Lipase
D) Phosphatidylcholine
  • 2. What is produced from PIP2 alongside diacylglycerol?
A) Jasmonic acid
B) Prostaglandin
C) Lecithin
D) Inositol triphosphate
  • 3. What is the role of phospholipids in prostaglandin signal pathways?
A) They stabilize oil-water interfaces
B) They act as second messengers
C) They inhibit lipase activity
D) They serve as raw material
  • 4. Which hormone is produced from phospholipids in plants?
A) Inositol triphosphate
B) Jasmonic acid
C) Diacylglycerol
D) Prostaglandin
  • 5. What function does jasmonic acid serve in plants?
A) Mediates defensive responses
B) Intervenes in long term depression
C) Acts as a G protein
D) Stabilizes oil-water interfaces
  • 6. Which phospholipid is a major component of egg yolk lecithin?
A) Phosphatidylglycerol
B) Phosphatidic acid
C) Phosphatidylcholine
D) Phosphatidylserine
  • 7. Why are phospholipids used in products like mayonnaise?
A) They are precursors to jasmonic acid
B) They act as second messengers
C) They trigger Gq signaling
D) They function as emulsifiers
  • 8. Which of these is listed as a natural phospholipid derivative?
A) DPPC
B) DOPS
C) Sphingomyelin
D) DMPA
  • 9. Which of these is a synthetic phosphatidylcholine derivative?
A) Egg PC
B) Soy PC
C) DMPC
D) Sphingomyelin
  • 10. What is the primary function of phospholipids at oil-water interfaces?
A) Signal transduction
B) Enzymatic cleavage
C) Stabilization
D) Hormone production
  • 11. Which model historically describes the membrane as a mosaic of lipid molecules acting as a solvent?
A) Crystalline lattice model
B) Static matrix model
C) Fluid mosaic model
D) Lipid polymorphism model
  • 12. What allows proteins and lipid molecules to move within the lipid matrix?
A) Lateral diffusion
B) Active transport
C) Vertical flipping
D) Osmotic pressure
  • 13. What substances contribute to membrane fluidity by hindering phospholipid packing?
A) Phosphoinositides
B) Ceramides
C) Sterols
D) Proteins
  • 14. What has superseded the fluid mosaic model according to the text?
A) The cell wall theory
B) The fluid-static model
C) Study of lipid polymorphism
D) The protein-only model
  • 15. Which phospholipid is also known as cephalin?
A) Phosphatidic acid
B) Phosphatidylcholine
C) Phosphatidylinositol
D) Phosphatidylethanolamine
  • 16. Which of the following is a type of phosphoinositide?
A) Sphingomyelin
B) Phosphatidic acid
C) Phosphatidylinositol 3-phosphate
D) Ceramide phosphorylcholine
  • 17. What is the abbreviated name for Phosphatidic acid?
A) PC
B) PA
C) PE
D) PS
  • 18. Which of these is a trisphosphate phosphoinositide?
A) PIP3
B) PI4P
C) PI3P
D) PI5P
  • 19. In the fluid mosaic model, what acts as the solvent?
A) Proteins
B) Cytosol
C) Lipid molecules
D) Sterols
  • 20. What are the two components of a phospholipid molecule?
A) Two hydrophilic heads and one hydrophobic tail
B) A hydrophilic head and two hydrophobic tails
C) A phosphate tail and two hydrophilic heads
D) One fatty acid head and two phosphate tails
  • 21. What usually connects the phosphate group to the fatty acid tails?
A) A glycerol molecule
B) A choline molecule
C) A glucose molecule
D) A serine molecule
  • 22. Which specific omega-3 fatty acids are found in marine phospholipids?
A) DHA and GLA
B) EPA and DHA
C) EPA and ALA
D) ALA and GLA
  • 23. Which organic molecules can modify the phosphate group?
A) Sterols, glycolipids, or proteins
B) Choline, ethanolamine, or serine
C) EPA, DHA, or amino acids
D) Glycerol, fatty acids, or glucose
  • 24. Which neurotransmitter synthesis is supported by phospholipids?
A) Serotonin
B) Adrenaline
C) Dopamine
D) Acetylcholine
  • 25. By what percentage do brain phospholipid levels potentially decline by age 80?
A) 20%
B) 10%
C) 50%
D) 5%
  • 26. What dietary source of phospholipids is linked to improved memory and mood?
A) Plant-based sterols
B) Egg white proteins
C) Milk fat globule membrane (MFGM)
D) Marine algae extracts
  • 27. What is the recommended daily intake of MFGM phospholipids for stress and cognitive benefits?
A) 1000–1200 mg
B) 50–100 mg
C) 300–600 mg
D) 100–200 mg
  • 28. What characteristic allows phospholipids to form lipid bilayers?
A) Hydrophilic
B) Hydrophobic
C) Amphiphilic
D) Crystalline
  • 29. What molecule is interspersed among phospholipids in eukaryotic cell membranes?
A) Choline
B) Sterol
C) Starch
D) Glucose
  • 30. What is the primary benefit of the combination of phospholipids and sterols in membranes?
A) Increased solubility
B) Energy storage
C) Fluidity and mechanical strength
D) Increased thickness
  • 31. Who identified the first phospholipid in 1847?
A) Robert Hooke
B) Louis Pasteur
C) Theodore Nicolas Gobley
D) Marie Curie
  • 32. What was the first phospholipid identified in biological tissues?
A) Sphingomyelin
B) Phosphatidylserine
C) Lecithin
D) Phosphatidylethanolamine
  • 33. What drives the formation of phospholipid bilayers in aqueous solutions?
A) Hydrogen bonding
B) Ionic attraction
C) Covalent bonding
D) Hydrophobic interactions
  • 34. What structural motif consists of two layers of oppositely oriented phospholipid molecules?
A) Lipid monolayer
B) Micelle
C) Phospholipid bilayer
D) Liposome
  • 35. Besides cell membranes, what other biological structures use phospholipid bilayers?
A) Cytoskeleton fibers
B) Mitochondrial matrix
C) Vesicles and virus coatings
D) Ribosomal subunits
  • 36. What substance faces the water in a lipid bilayer?
A) Fatty acid residues
B) Sterol rings
C) Hydrophobic tails
D) Hydrophilic heads
  • 37. What are liposomes often composed of?
A) Cholesterol crystals
B) Phosphatidylcholine-enriched phospholipids
C) Pure water and salt
D) Synthetic polymers only
  • 38. Which drug is mentioned in the context of ethosomal formulation for transdermal delivery?
A) Aspirin
B) Insulin
C) Penicillin
D) Ketoconazole
  • 39. Which field of study is used to explore biomolecules like phospholipids and their conformations to understand diseases?
A) Proteomics
B) Lipidomics
C) Metabolomics
D) Genomics
  • 40. What optical property do phospholipids exhibit?
A) Phosphorescence
B) Fluorescence
C) Birefringence
D) Opacity
  • 41. What is used to obtain an image of vesicle walls based on birefringence?
A) Electron microscope
B) X-ray diffraction
C) Simple magnifying glass
D) Cross polarisers in a microscope
  • 42. How do oil chemists often estimate the mass of phospholipids?
A) Measuring electrical conductivity
B) Determining total phosphorus abundance
C) Counting individual molecules
D) Weighing the entire sample
  • 43. Which technique provides absolute methods of analysis for lipid profiling?
A) Colorimetry
B) Simple titration
C) NMR spectroscopy
D) Visual inspection
  • 44. What does HPLC-ELSD provide in phospholipid analysis?
A) Relative values
B) Total phosphorus count
C) Molecular structure
D) Absolute mass
  • 45. Why are phospholipids used in drug formulations?
A) To increase the shelf life indefinitely
B) To change the drug's color
C) To make the drug taste better
D) To improve bio-availability
  • 46. What technique is used to quantify lipid order in supported bilayers?
A) Dual polarisation interferometry
B) Infrared spectroscopy
C) Gas chromatography
D) Mass spectrometry
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