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COVID-19 vaccine - Quiz
Contributed by: Hale
  • 1. What was the primary goal of the initial SARS-CoV-2 vaccines?
A) Preventing all transmission
B) Eradicating the virus globally
C) Reducing mutation rates of the virus
D) Preventing symptomatic, often severe, illness
  • 2. Which of these vaccines is a single-dose vaccine?
A) Janssen
B) Razi Cov Pars
C) Pfizer–BioNTech
D) Soberana
  • 3. Which protein is the primary target for COVID-19 vaccines because it induces a strong immune response?
A) Nucleocapsid protein
B) Envelope protein
C) Membrane protein
D) Spike protein
  • 4. Why are nucleocapsid proteins being investigated for vaccine development?
A) They completely block viral entry
B) They are easier to manufacture
C) They have no genomic variability
D) They induce a robust T-cell response
  • 5. What is the purpose of the 2P mutation in some synthetic vaccines?
A) Locking the spike protein into its prefusion configuration
B) Preventing lipid degradation
C) Creating a live attenuated virus
D) Increasing the speed of mRNA production
  • 6. How is mRNA delivered into human cells in COVID-19 vaccines?
A) Mixed with attenuated live virus
B) Injected directly into cell nuclei
C) Encapsulated in lipid nanoparticles
D) Attached to viral vectors
  • 7. Which COVID-19 mRNA vaccine failed in clinical trials?
A) CVnCoV
B) Comirnaty
C) Mnexspike
D) Spikevax
  • 8. What component is most likely responsible for severe allergic reactions to mRNA vaccines?
A) Lipid nanoparticles
B) The preservative agents
C) The mRNA strands
D) The nucleoside modifications
  • 9. What is the brand name of the Moderna COVID-19 vaccine version approved in May 2025?
A) Mnexspike
B) Convidecia
C) Comirnaty
D) Spikevax
  • 10. How many vaccine technology platforms were under research in July 2021?
A) Twelve
B) Exactly three
C) At least nine
D) Only two
  • 11. When did the first clinical trials for COVID-19 vaccines begin?
A) August 2020
B) January 2021
C) March 2020
D) December 2019
  • 12. Who received the 2023 Nobel Prize in Physiology or Medicine for mRNA vaccine development?
A) The World Health Organization
B) Katalin Karikó and Drew Weissman
C) Pfizer and BioNTech
D) Moderna and Novavax
  • 13. What happens to vaccine-induced immunity over time?
A) It wanes
B) It disappears immediately
C) It becomes permanent
D) It increases
  • 14. Are COVID-19 vaccines considered safe for those who are breastfeeding?
A) Only with medical supervision
B) No
C) Yes
D) Only after weaning
  • 15. How many deaths were estimated to be prevented by the vaccine according to the Journal of Paediatrics and Child Health?
A) 20 to 25 million
B) 1 to 3 million
C) 14.4 to 19.8 million
D) 5 to 10 million
  • 16. Which of these is a common side effect of the vaccine?
A) Permanent paralysis
B) Autoimmune disease
C) Chronic organ failure
D) Myalgia
  • 17. How many vaccine doses had been administered worldwide as of August 2024?
A) Over 50 billion
B) Over 13 billion
C) Exactly 10 billion
D) Under 5 billion
  • 18. What previous research helped accelerate the development of COVID-19 vaccines?
A) Ebola research
B) Zika research
C) Influenza research
D) SARS and MERS research
  • 19. What is the purpose of variant-adapted vaccines?
A) To cure long COVID
B) To replace initial vaccines entirely
C) To serve as booster doses
D) To act as a treatment for infected individuals
  • 20. Which groups were typically prioritized in phased distribution plans?
A) The wealthiest citizens
B) The elderly and healthcare workers
C) Only government officials
D) Children and students
  • 21. Prior to COVID-19, how long did it typically take to produce a vaccine for an infectious disease?
A) A few months
B) Several years
C) Less than one year
D) Over two decades
  • 22. Which of the following animal coronaviruses has a vaccine available?
A) Equine influenza
B) Feline coronavirus
C) Bovine rotavirus
D) Porcine circovirus
  • 23. Prior to COVID-19, what was the status of human coronavirus vaccines?
A) One was approved for SARS
B) Two were approved for MERS
C) Several were widely used
D) None existed
  • 24. What is the status of a proven safe and effective vaccine for SARS in humans?
A) Approved in 2005
B) None exists
C) Approved in 2020
D) Approved in 2006
  • 25. As of March 2020, how many MERS vaccines had completed Phase I clinical trials in humans?
A) Five
B) One
C) Zero
D) Three
  • 26. What type of technology was used for the MERS vaccine that completed Phase I trials by March 2020?
A) Inactive virus
B) mRNA-based
C) DNA-based
D) Live attenuated
  • 27. How long does it typically take to develop vaccines using inactive or weakened viruses grown in eggs?
A) Less than one year
B) Six months
C) More than a decade
D) Two to three years
  • 28. In what year did Moderna begin human testing of an mRNA vaccine?
A) 2020
B) 2015
C) 2005
D) 2010
  • 29. For which disease was viral vector technology previously cleared before being used for COVID-19?
A) Influenza
B) SARS
C) MERS
D) Ebola
  • 30. Which animal is mentioned as a subject for SARS and MERS vaccine testing?
A) Primates only
B) Birds only
C) Humans only
D) Non-human animals
  • 31. Besides DNA-based vaccines, what other type of MERS vaccine was in progress as of March 2020?
A) mRNA-based
B) Viral-vectored
C) Inactivated virus
D) Protein subunit
  • 32. What kind of virus is typically used as a base for viral vector COVID-19 vaccines?
A) Influenza virus
B) Rhinovirus
C) Coronavirus
D) Adenovirus
  • 33. How do viral vector vaccines produce an immune response?
A) By transferring mRNA directly to the nucleus
B) By producing an antigen via encoded DNA
C) By using heat-killed viral particles
D) By injecting live coronavirus
  • 34. What Ad serotype does Sputnik V use for its second dose?
A) Ad10
B) Ad2
C) Ad5
D) Ad26
  • 35. How are viruses inactivated in inactivated virus vaccines?
A) By removing their DNA
B) By heat or formaldehyde
C) By freezing them in liquid nitrogen
D) By coating them in protein subunits
  • 36. Which vaccine is an example of an inactivated virus vaccine?
A) CoronaVac
B) Novavax
C) ZF2001
D) Convidecia
  • 37. How is the Novavax vaccine produced?
A) By infecting moth cells with a modified baculovirus
B) By using cultured adenovirus
C) By chemical synthesis of proteins
D) By heat-inactivation of SARS-CoV-2
  • 38. What are Virus-like particle (VLP) vaccines lacking?
A) Protein antigens
B) RNA or DNA
C) A lipid membrane
D) Spike proteins
  • 39. Which vaccine was approved for use as a booster in the EU in 2023?
A) Covaxin
B) QazVac
C) Bimervax
D) Sputnik V
  • 40. How many COVID-19 vaccines had received authorization in one or more countries by the end of 2022?
A) 10
B) 25
C) 50
D) 100
  • 41. Which vaccine was investigated for potential non-specific effects on the immune system against COVID-19?
A) Sputnik V
B) Razi Cov Pars
C) Pneucolin
D) BCG vaccine
  • 42. Which specific nasal immune factor are intranasal vaccines designed to stimulate?
A) IgE
B) IgG
C) IgM
D) IgA
  • 43. Which country authorized the Razi Cov Pars intranasal vaccine in October 2021?
A) Iran
B) China
C) Russia
D) India
  • 44. What is the primary route of administration for most current coronavirus vaccines?
A) Intranasal spray
B) Intravenous infusion
C) Intramuscular injection
D) Oral administration
  • 45. When was a combined messenger RNA vaccine for influenza and COVID-19 introduced?
A) 2024
B) 2022
C) 2026
D) 2025
  • 46. What potential benefit of intranasal vaccines addresses needle phobia?
A) Ease of administration without needles
B) Requirement for fewer doses
C) Faster manufacturing time
D) Higher viral load suppression
  • 47. What type of immune system feature do intranasal vaccines target?
A) Innate cellular immunity
B) Mucosal immunity
C) Passive immunity
D) Systemic immunity
  • 48. Which vaccine was authorized in Russia as Sputnik Nasal in April 2022?
A) The first viral component of Sputnik V
B) iNCOVACC
C) Razi Cov Pars
D) Pneucolin
  • 49. In December 2022, which country approved Pneucolin as a booster vaccine?
A) USA
B) China
C) Iran
D) India
  • 50. When were the results of the SpFN Phase I clinical trial published?
A) March 2022
B) June 2025
C) May 2024
D) April 2022
  • 51. Which country is developing the universal vaccine candidate VBI-2902?
A) China
B) Canada
C) France
D) UK
  • 52. What theory suggests a broader range of strains can be targeted?
A) Targeting the entire viral genome
B) Targeting the receptor-binding domain
C) Focusing on pediatric populations
D) Targeting only the nasal cavity
  • 53. In June 2025, which agency made data from COVID-19 mRNA vaccine applications publicly available?
A) Walter Reed Army Institute of Research
B) Chinese Center for Disease Control
C) White House
D) European Medicines Agency
  • 54. What is one factor that obstructed research at universities during the pandemic?
A) Physical distancing
B) Overabundance of funding
C) Governmental bans on science
D) Lack of interest
  • 55. Why do companies have to compete for trial participants in Phases II-III?
A) Changing transmission rates make the virus a 'moving target'
B) International borders are closed to research
C) Participants prefer placebo groups
D) The vaccines are too expensive
  • 56. What is the alternative name for the Vaccines pillar of the ACT-Accelerator?
A) Vaccine Bank
B) Operation Warp Speed
C) R&D Blueprint
D) COVAX
  • 57. Which of the following is NOT one of the pillars of the ACT-Accelerator?
A) Diagnostics
B) Health Systems Connector
C) Manufacturing
D) Therapeutics
  • 58. What is the primary function of the US agency BARDA?
A) Regulating drug safety laws
B) Developing medical school curricula
C) Managing global vaccine distribution
D) Funding disease-fighting technology
  • 59. What was the name of the US fast-track vaccine program announced in May 2020?
A) The Vaccine Bank
B) Operation Warp Speed
C) The R&D Blueprint
D) ACT-Accelerator
  • 60. Which pharmaceutical company is specifically mentioned as having experience in large-scale vaccine production?
A) Novavax
B) Moderna
C) Johnson & Johnson
D) Pfizer
  • 61. According to the text, what is the primary cause of COVID-19 transmission?
A) Severe infections
B) Environmental surfaces
C) Asymptomatic carriers only
D) Mild infections
  • 62. What was the vaccine efficacy against pre-Omicron variants in the first months after vaccination?
A) Around 95%
B) Around 77%
C) Around 50%
D) Around 26%
  • 63. What was the vaccine efficacy against Omicron variants?
A) 50%
B) 90%
C) 26%
D) 77%
  • 64. What restored the protection against infections after the initial waning?
A) Boosters
B) Placebos
C) Therapeutics
D) Wait times
  • 65. Which international organization is a partner in the ACT-Accelerator?
A) World Health Organization
B) Red Cross
C) United Nations
D) Doctors Without Borders
  • 66. What is true about antibody titers regarding individual protection?
A) Individual protection titers are clearly defined
B) Individual protection titers are determined by weight
C) Individual protection titers are not associated with immunity
D) Individual protection titers remain unknown
  • 67. What is the recommended booster schedule for care home residents as of March 2022?
A) Every month
B) Every two years
C) Every six months
D) Once per lifetime
  • 68. What percentage of protection against long COVID is provided by three doses of a vaccine?
A) 70%
B) 19%
C) 90%
D) 43%
  • 69. What kind of studies provided the evidence for vaccine effectiveness against long COVID?
A) Randomized clinical trials
B) Computer simulations
C) Observational studies
D) Case reports only
  • 70. Did large randomized control trials on COVID-19 vaccines include long COVID as an outcome measure?
A) Yes, but only in the Moderna trials
B) Yes, but only in the Pfizer trials
C) Yes, in all of them
D) No
  • 71. What is another term for the mix-and-match vaccination method?
A) Single-dose regimen
B) Homologous vaccination
C) Standard regimen
D) Heterologous vaccination
  • 72. How are the risks of serious illness from COVID-19 compared to the risks from vaccines?
A) The risks from COVID-19 are far higher.
B) The risks are about the same.
C) The risks from the vaccine are higher.
D) There is no way to compare the risks.
  • 73. What phenomenon explains reports of adverse effects in placebo groups during vaccine trials?
A) Inflammation.
B) Allergic reaction.
C) Intramuscular trauma.
D) Nocebo effect.
  • 74. In the February 2022 study, how many deaths were reported out of 250 million Americans vaccinated?
A) 250.
B) 2,700.
C) 17.
D) 55.
  • 75. Who typically reports stronger side effects?
A) People with chronic illness only.
B) Older people.
C) Infants.
D) Younger people.
  • 76. How often does COVID-19 vaccination-related enlargement of lymph nodes occur after two doses?
A) 16%.
B) 11.6%.
C) 20%.
D) 5%.
  • 77. How long does it take for menstrual cycle lengths to return to normal after vaccination?
A) One week.
B) Two menstrual cycles.
C) Six months.
D) One year.
  • 78. Which type of vaccine generally has weaker or less common side effects?
A) Inactivated vaccines.
B) DNA vaccines.
C) Vector vaccines.
D) mRNA vaccines.
  • 79. How many cases of cerebral venous sinus thromboses (CVST) were recorded by the Paul Ehrlich Institute in Germany?
A) 9.
B) 31.
C) 250.
D) 73.
  • 80. What is the approximate mortality rate of people who experience anaphylaxis following a COVID-19 vaccination?
A) 0.5%
B) 1.07%
C) 0.015%
D) 5%
  • 81. Which group is identified as having the highest risk of myocarditis following COVID-19 vaccination?
A) Young males
B) Immunocompromised individuals
C) Children under 5
D) Elderly females
  • 82. Which digital platform did India make open to the global community to help manage vaccination distribution?
A) CoWIN
B) VigiBase
C) EudraVigilance
D) Aarogya Setu
  • 83. What action did the US government announce on May 5, 2021, regarding intellectual property for COVID-19 vaccines?
A) Remains neutral on the issue
B) Supports stricter patent enforcement
C) Supports waiving intellectual property protections
D) Proposed a ban on foreign vaccine exports
  • 84. Which countries might lose more money in absolute terms due to vaccine inequity?
A) Countries with no vaccine supply.
B) Poor countries.
C) Countries with low tourism rates.
D) Rich countries.
  • 85. Which countries lose a higher percentage of GDP due to vaccine inequity?
A) Countries in the northern hemisphere.
B) Island nations.
C) Poor countries.
D) Rich countries.
  • 86. What characterized the early 2021 COVID-19 vaccine distribution in the United States?
A) There was no interest in getting vaccinated.
B) Supply significantly exceeded demand.
C) Vaccines were readily available for everyone.
D) Demand significantly exceeded supply.
  • 87. Who created a program in the San Francisco Bay Area that monitored over 100 provider websites?
A) A group of pharmacy owners.
B) The state health department.
C) High school students only.
D) Mukesh Aggarwal.
  • 88. What was the name of the Twitter bot launched by high school students in the Bay Area?
A) @VaccineHunter
B) @BayVaccine
C) @CovaxSF
D) @CVSBot
  • 89. What platform did independently developed bots monitor in California?
A) MyTurn.
B) HealthPortal.
C) VaccineAlert.
D) GlobalVaccineTracker.
  • 90. Why did many volunteer-run tracking systems discontinue in mid-2021?
A) The websites were hacked by competitors
B) The developers lost interest
C) They were banned by federal law
D) The need for intensive monitoring declined
  • 91. What allowed others to monitor appointment endpoints directly?
A) Open-source scripts
B) Telephone hotlines
C) Physical paper maps
D) Official government apps
  • 92. Which specific U.S. state was mentioned regarding crowd-sourced vaccine reports?
A) Florida
B) California
C) New York
D) Texas
  • 93. Which US government official published the notice of declaration under the PREP Act in February 2020?
A) Joe Biden
B) Ron DeSantis
C) Alex Azar
D) Donald Trump
  • 94. Under the US PREP Act declaration, what is the exception that allows for liability claims against vaccine manufacturers?
A) Willful misconduct
B) High pricing
C) Product spoilage
D) Negligence
  • 95. Which country granted Pfizer legal indemnity for its COVID-19 vaccine in December 2020?
A) United Kingdom
B) Argentina
C) Brazil
D) France
  • 96. What type of authorization did COVID-19 vaccines initially receive in the European Union?
A) Conditional marketing authorization
B) Liability exemption
C) Standard authorization
D) Emergency use permit
  • 97. When were EU conditional marketing authorizations for COVID-19 vaccines changed to standard authorizations?
A) September 2022
B) December 2020
C) November 2023
D) February 2020
  • 98. What did the governor of Florida petition to convene in December 2022 regarding COVID-19 vaccines?
A) A congressional hearing
B) A grand jury
C) A Supreme Court trial
D) An international tribunal
  • 99. Under which act did Texas sue Pfizer in November 2023?
A) Public Health Emergency Act
B) Consumer Vaccine Safety Act
C) PREP Act
D) Texas Deceptive Trade Practices Act
  • 100. In which country did the #ChinaAngVirus campaign originate?
A) Philippines
B) Saudi Arabia
C) United States
D) China
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