- 1. What kind of antigens do NKT cells recognize?
A) Peptides
B) Nucleic acids
C) Lipids and glycolipids
D) Polysaccharides
- 2. Which molecule presents antigens to NKT cells?
A) CD161
B) CD1d
C) MHC class II
D) MHC class I
- 3. What percentage of peripheral blood T cells are NKT cells?
A) Approximately 1%
B) Approximately 10%
C) Approximately 25%
D) Approximately 5%
- 4. What is the original marker used to identify NKT cells in mice?
A) CD56
B) NK1.1
C) CD4
D) CD8
- 5. Which microorganism is cited as being recognized by NKT cells due to its glycolipids?
A) Mycobacterium
B) Candida
C) Streptococcus
D) Influenza virus
- 6. Which transcription factor is critical for the development of iNKT cells?
A) PLZF
B) Gata3
C) Runx3
D) Rorc
- 7. Where do NKT cells differentiate into effector cells?
A) Spleen
B) Thymus
C) Bone marrow
D) Lymph nodes
- 8. What interaction is required for the costimulation of NKT cells during differentiation?
A) SLAM-SLAM interaction
B) NK1.1-CD1d interaction
C) CD1d-TCR interaction
D) MHC-TCR interaction
- 9. What is the result of elevated TCR signaling in NKT thymic precursors?
A) Downregulation of PLZF
B) Upregulation of Egr2
C) Immediate cytokine release
D) Apoptosis
- 10. Which cytokine is mentioned as being related to PLZF-regulated genes?
A) IL-2
B) IL-4
C) IL-10
D) TNF-alpha
- 11. Which lipid molecule was previously thought to be important for NKT development but lacks a synthesis enzyme in humans?
A) Sphingomyelin
B) Ceramide
C) iGb3
D) Cholesterol
- 12. In the lineage differentiation model, which subsets can a thymic T cell develop into before stage zero?
A) NK1.1+, NK1.1-, and CD56+
B) CD4+, CD8+, and double negative
C) NKT1, NKT2, and NKT17
D) Type 1, Type 2, and Type 3
- 13. NKT cells co-express an alpha-beta T-cell receptor with markers typically found on what other cell type?
A) Dendritic cells
B) Macrophages
C) B cells
D) Natural killer cells
- 14. What is a distinguishing feature of 'type 1' NKT cells compared to conventional T cells?
A) Limited TCR diversity
B) Lack of TCR expression
C) High MHC class II expression
D) Absence of CD1d binding
- 15. Besides IFN-gamma and IL-4, which other cytokine production is associated with PLZF?
A) IL-12
B) IL-3
C) IL-1
D) IL-6
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