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Central dogma of molecular biology - Quiz
Contributed by: Blake
  • 1. What is RNA replication?
A) The translation of RNA into protein
B) The synthesis of DNA from RNA
C) The degradation of RNA molecules
D) The copying of one RNA to another
  • 2. What are the enzymes that copy RNA to new RNA called?
A) Reverse transcriptases
B) DNA-dependent RNA polymerases
C) Ribosomal peptide synthetases
D) RNA-dependent RNA polymerases
  • 3. Where are RNA-dependent RNA polymerases also found, besides viruses?
A) Only in prions
B) Exclusively in bacterial plasmids
C) In many eukaryotes
D) Only in prokaryotes
  • 4. What role do RNA-dependent RNA polymerases play in eukaryotes?
A) DNA replication
B) Nonribosomal peptide synthesis
C) Intein excision
D) RNA silencing
  • 5. What is RNA editing?
A) An RNA sequence being altered by a protein complex and a guide RNA
B) The creation of DNA from a protein template
C) The conversion of proteins into RNA
D) The destruction of messenger RNA
  • 6. What does the central dogma of molecular biology state about sequential information once it passes from nucleic acid to protein?
A) It is immediately destroyed by enzymes
B) It must be converted into carbohydrates
C) It can easily flow back to nucleic acid
D) It cannot flow back from protein to nucleic acid
  • 7. What is post-translational modification?
A) The replication of prions in host cells
B) The direct translation of proteins back into DNA
C) The synthesis of RNA without a DNA template
D) Editing of protein amino-acid sequences by appropriate enzymes after translation
  • 8. Does post-translational modification involve proteins transferring information to nucleic acid?
A) Yes
B) Only in eukaryotes
C) No
D) Only in viruses
  • 9. What synthesizes nonribosomal peptides?
A) Ribosomes
B) RNA-dependent RNA polymerases
C) Homing endonucleases
D) Nonribosomal peptide synthetases
  • 10. What structural features often differentiate nonribosomal peptides from ribosome-synthesized proteins?
A) Cyclic or branched structures and non-proteinogenic amino acids
B) Double-stranded nucleic acid backbones
C) Linear structures and standard amino acids only
D) Lack of any peptide bonds
  • 11. What is an example of nonribosomal peptides?
A) Most DNA polymerases
B) Prion proteins
C) All ribosomal enzymes
D) Some of the antibiotics
  • 12. What is an intein?
A) A non-proteinogenic amino acid
B) A guide RNA used in RNA editing
C) A parasitic segment of a protein that is able to excise itself
D) A type of virus that replicates RNA
  • 13. What does an intein do as amino acid chains emerge from the ribosome?
A) Destroys the entire protein backbone
B) Converts the protein into a nucleic acid
C) Excises itself from the chain and rejoins the remaining portions
D) Replicates the ribosomal RNA
  • 14. What domain do most inteins contain?
A) A nonribosomal peptide synthetase domain
B) An RNA silencing domain
C) A homing endonuclease or HEG domain
D) A prion conformation domain
  • 15. What does the HEG domain initiate upon contacting an intein-free copy of the parent gene?
A) The immediate degradation of the host cell
B) The synthesis of nonribosomal antibiotics
C) The DNA double-stranded break repair mechanism
D) The reversal of the central dogma
  • 16. What are prions?
A) Proteins of particular amino acid sequences in particular conformations
B) Enzymes that edit RNA sequences
C) Nonribosomal peptide synthetases
D) Small RNA-dependent polymerases found in eukaryotes
  • 17. How do prions propagate themselves in host cells?
A) By translating RNA directly into new prions
B) By making conformational changes in other molecules of protein with the same amino acid sequence
C) By excising themselves from protein backbones
D) By copying their own nucleic acid sequences
  • 18. What is the information flow in some types of prion in fungi?
A) RNA → DNA → Protein
B) Protein → Nucleic acid
C) Nucleic acid → Protein → Nucleic acid
D) Protein → Protein
  • 19. Which scientists argued that prion-mediated inheritance violates the central dogma?
A) Watson and Crick
B) Rosalind Ridley
C) Alain E. Bussard and Eugene Koonin
D) Not mentioned in the text
  • 20. What did Rosalind Ridley write regarding the prion hypothesis and the central dogma?
A) Prions prove that information flows backward from proteins to DNA
B) The prion hypothesis is not heretical to the central dogma because it does not claim that proteins replicate
C) The prion hypothesis completely destroys the central dogma by proving protein replication
D) Proteins are capable of manufacturing nucleic acid sequences
  • 21. Who first stated the central dogma in 1957?
A) Rosalind Franklin
B) Gregor Mendel
C) James Watson
D) Francis Crick
  • 22. In what year was Francis Crick's original statement of the central dogma published?
A) 1958
B) 1965
C) 1970
D) 1955
  • 23. In what year was Crick's Nature paper re-stating the central dogma published?
A) 1970
B) 1980
C) 1958
D) 1965
  • 24. Who published the popular but incorrect second version of the central dogma?
A) Francis Crick
B) Gregor Mendel
C) James Watson
D) Watson and Crick
  • 25. In what year was James Watson's first edition of The Molecular Biology of the Gene published?
A) 1958
B) 1970
C) 1975
D) 1965
  • 26. Between Crick's and Watson's versions of the central dogma, which one remains valid today?
A) Crick's original version
B) Neither remains valid
C) Watson's version
D) Both are equally valid
  • 27. What type of polymers are DNA, RNA, and polypeptides?
A) Cross-linked polysaccharides
B) Linear heteropolymers
C) Branched homopolymers
D) Circular lipids
  • 28. In linear heteropolymers, each monomer is connected to at most how many other monomers?
A) Two
B) One
C) Four
D) Three
  • 29. How are the transfers of information from one biopolymer to another described?
A) Chaotic and reversible
B) Inconsistent and unstable
C) Random and spontaneous
D) Faithful, deterministic transfers
  • 30. In groups of how many are proteins encoded?
A) Three
B) Two
C) One
D) Four
  • 31. What are groups of three bases encoding proteins called?
A) Codons
B) Templates
C) Polymers
D) Monomers
  • 32. Which lifeforms or structures are specifically noted as using different translations from the standard codon table?
A) Somatic cells
B) Bacterial ribosomes
C) Human mitochondria
D) Plant chloroplasts
  • 33. What complex group of proteins performs DNA replication?
A) The replisome
B) RNA polymerase
C) Transcription factors
D) Ribosomes
  • 34. During DNA replication, information is copied from the parent strand to which strand?
A) Pre-mRNA transcript
B) Complementary daughter strand
C) Template mRNA strand
D) Polypeptide chain
  • 35. What is the process by which information in a section of DNA is replicated into mRNA called?
A) Translation
B) Splicing
C) Replication
D) Transcription
  • 36. What is the primary transcript called in eukaryotic cells?
A) Polypeptide
B) Pre-mRNA
C) Mature mRNA
D) Complementary DNA
  • 37. What process follows the addition of the 5' cap and poly-A tail to pre-mRNA?
A) Replication
B) Splicing
C) Duplication
D) Translation
  • 38. Where does translation occur for mature mRNA?
A) Inside the cell nucleus
B) At a ribosome
C) At the Golgi apparatus
D) Within the endoplasmic reticulum
  • 39. Where is the site of translation in eukaryotic cells?
A) The cytoplasm
B) The nucleolus
C) The nuclear pore
D) The cell nucleus
  • 40. What is the usual initiator codon that begins translation?
A) UAG
B) AUG
C) UGA
D) UAA
  • 41. What does the acronym AUG stand for in the text?
A) Alanine-uracil-glycine
B) Adenine-thymine-guanine
C) Adenine-uracil-cytosine
D) Adenine-uracil-guanine
  • 42. Which of the following is a stop codon that ends translation?
A) UAA
B) AUG
C) GUA
D) UCA
  • 43. Which triplet can also serve as a stop codon?
A) ACC
B) MET
C) UGA
D) AUG
  • 44. Which of the following is listed in the text as a stop codon?
A) AUG
B) GUU
C) UAG
D) ACU
  • 45. What are the inside 'discarded' sections called when some proteins excise internal segments?
A) Codons
B) Cofactors
C) Inteins
D) Retroviruses
  • 46. What is the family of enzymes involved in reverse transcription called?
A) Reverse Transcriptase
B) Elongation factors
C) Initiation factors
D) Chaperone proteins
  • 47. Who pointed out to Crick that he did not understand the correct use of the word dogma?
A) August Weismann
B) Jacques Monod
C) Albert Einstein
D) Horace Freeland Judson
  • 48. How did Crick view religious beliefs?
A) As experimentally proven
B) As absolute truths
C) Without foundation
D) As central dogma
  • 49. What kind of support did Crick's central dogma have at the time he named it?
A) Universal acceptance
B) Extensive experimental support
C) Little direct experimental support
D) No theoretical backing
  • 50. Who recorded Crick's explanation of the word dogma in 'The Eighth Day of Creation'?
A) Francis Crick
B) Jacques Monod
C) August Weismann
D) Horace Freeland Judson
  • 51. How did Crick describe the word dogma in his interview with Judson?
A) A religious law
B) A catch phrase
C) A proven fact
D) A sacred truth
  • 52. Who proposed the Weismann barrier?
A) August Weismann
B) Francis Crick
C) Horace Freeland Judson
D) Jacques Monod
  • 53. In what year was the Weismann barrier proposed?
A) 1900
B) 1892
C) 1882
D) 1953
  • 54. How are germ cell lineages described in the context of the Weismann barrier?
A) Somatic
B) Disposable
C) Temporary
D) Immortal
  • 55. How are somatic cells described in the context of the Weismann barrier?
A) Germline
B) Immortal
C) Permanent
D) Disposable
  • 56. In what terms was the Weismann barrier's view of life expressed?
A) Non-molecular terms
B) Molecular terms
C) Religious terms
D) Quantum terms
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