ThatQuiz Test Library Take this test now
Epidermis - Quiz
Contributed by: Chadwick
  • 1. When does epidermal organogenesis begin?
A) During the formation of the stratum corneum
B) After birth
C) Before neurulation
D) After neurulation
  • 2. What is the initial structure of the epidermis in most vertebrates?
A) Cornified
B) One-layered
C) Two-layered
D) Three-layered
  • 3. What is the temporary outer layer of the early epidermis called?
A) Stratum germinativum
B) Embryonic periderm
C) Stratum spinosum
D) Stratum corneum
  • 4. What is another name for the inner basal layer of the epidermis?
A) Malpighian layer
B) Stratum granulosum
C) Embryonic periderm
D) Stratum germinativum
  • 5. The stratum germinativum divides to form which outer layer?
A) Stratum corneum
B) Stratum spinosum
C) Embryonic periderm
D) Stratum granulosum
  • 6. What are the basal and spinous layers together called?
A) Granular layer
B) Periderm
C) Malpighian layer
D) Cornified layer
  • 7. Whose name is associated with the Malpighian layers?
A) Louis Pasteur
B) Robert Hooke
C) Marcello Malpighi
D) Gregor Mendel
  • 8. The Malpighian layers divide to form which superficial layer?
A) Stratum corneum
B) Dermal layer
C) Stratum granulosum
D) Embryonic periderm
  • 9. Do cells in the stratum granulosum divide?
A) Only after birth
B) No
C) Yes
D) Only during stress
  • 10. What do cells in the stratum granulosum form from keratin granules?
A) Keratinocytes
B) Periderm cells
C) Glucocorticoids
D) Fibroblasts
  • 11. What is the outermost epidermal layer called?
A) Stratum spinosum
B) Stratum corneum
C) Stratum germinativum
D) Stratum granulosum
  • 12. What shape do cells become in the cornified layer?
A) Round spheres
B) Cube-shaped
C) Flattened sacks
D) Elongated fibers
  • 13. Where are the nuclei located in the cells of the stratum corneum?
A) In the exact center
B) At one end of the cell
C) Scattered throughout
D) They have no nuclei
  • 14. How many milligrams of skin flakes are shed every hour?
A) 30 – 90 milligrams
B) 1 – 5 grams
C) 10 – 20 milligrams
D) 100 – 200 milligrams
  • 15. How many grams of skin flakes are shed per day?
A) 5.0 - 10.0 grams
B) 0.01 - 0.05 grams
C) 0.720 - 2.16 grams
D) 20.0 - 50.0 grams
  • 16. What type of growth factor is Transforming growth factor Alpha (TGFα)?
A) Autocrine growth factor
B) Inhibitory growth factor
C) Endocrine growth factor
D) Paracrine growth factor
  • 17. What is the function of TGFα in basal cells?
A) Stop cell division
B) Regulate dermal fibroblasts
C) Stimulate their own division
D) Produce keratin granules
  • 18. What is another name for Keratinocyte growth factor?
A) TGFα
B) TGFβ
C) FGF2
D) FGF7
  • 19. What type of growth factor is KGF?
A) Autocrine growth factor
B) Paracrine growth factor
C) Endocrine growth factor
D) Hormonal factor
  • 20. Where is KGF produced?
A) Stratum corneum
B) Underlying dermal fibroblasts
C) Stratum granulosum
D) Embryonic periderm
  • 21. What is regulated by KGF?
A) Production of sweat
B) Hydration of the stratum corneum
C) Proliferation of basal cells
D) Shedding of skin flakes
  • 22. What gives the epidermis its mechanical strength?
A) Cytoskeletal proteins linked to cell-cell junctions
B) High water content
C) Loose fat deposits
D) Autocrine growth factors
  • 23. What inhibits the passage of external chemicals into the body?
A) Highly organized lipids, acids, hydrolytic enzymes, and antimicrobial peptides
B) Loose cellular junctions
C) High external humidity
D) Glucocorticoids
  • 24. What combat infection using humoral and cellular constituents in the epidermis?
A) Chemical barrier
B) Physical barrier
C) Non-pathogenic microorganisms
D) Immunologically active barrier
  • 25. What happens to the water content of the stratum corneum towards the surface?
A) It increases
B) It fluctuates wildly
C) It drops
D) It remains constant
  • 26. What approximate pH makes the epidermis hostile to many microorganisms?
A) 5.0
B) 9.0
C) 3.0
D) 7.0
  • 27. How do non-pathogenic microorganisms help defend the epidermis?
A) By increasing skin pH
B) By absorbing UV light
C) By breaking down keratinocytes
D) By competing for food and producing inhibitory chemical secretions
  • 28. What hormone increases during psychological stress to compromise the stratum corneum?
A) Insulin
B) Adrenaline
C) Thyroxine
D) Glucocorticoids
  • 29. What effect does psychological stress have on the barrier function?
A) It increases cell division
B) It has no effect
C) It strengthens it
D) It compromises it
  • 30. What environmental shift can alter stratum corneum hydration and allow pathogen entry?
A) Changes in atmospheric pressure
B) Sudden and large shifts in humidity
C) Exposure to UV light
D) Gradual temperature drops
  • 31. The epidermis provides mechanical resistance against what kind of injury?
A) Internal organ failure
B) Severe trauma
C) Bone fractures
D) Minor injury
  • 32. Oxidative stress protection by the epidermis is primarily against what?
A) Infrared heat
B) Radio waves
C) X-rays
D) UV light
  • 33. What is the outermost of the three major layers that constitute the skin?
A) Dermis
B) Epidermis
C) Hypodermis
D) Basement membrane
  • 34. What is the maximum thickness of the epidermis mentioned in the text?
A) 31.2 μm
B) 1000 μm
C) 596.6 μm
D) 90 μm
  • 35. What type of epithelium is the human epidermis an example of?
A) Stratified squamous epithelium
B) Simple columnar epithelium
C) Pseudostratified epithelium
D) Simple squamous epithelium
  • 36. How does the epidermis primarily receive its nourishment?
A) Diffused oxygen from surrounding air
B) Dermal blood vessels via direct contact
C) Arterioles and venules
D) Blood capillaries inside the layer
  • 37. Which transmembrane proteins form the adherens junctions between epidermal cells?
A) Keratins
B) Corneodesmosomes
C) Cadherins
D) Melanocytes
  • 38. How many layers of anucleated corneocytes typically compose the cornified layer?
A) About 5 layers
B) About 50 layers
C) About 15 layers
D) About 2 layers
  • 39. What separates the epidermis from the underlying dermis?
A) Basement membrane
B) Rete ridges
C) Lamellar bodies
D) Plasma membrane
  • 40. What are epidermal thickenings that extend downward between dermal papillae called?
A) Corneodesmosomes
B) Rete ridges
C) Hemidesmosomes
D) Cadherins
  • 41. What happens to differentiating cells as they delaminate from the basement membrane?
A) They are displaced outward
B) They divide into stem cells
C) They remain stationary
D) They move inward
  • 42. In normal skin, how does the rate of keratinocyte production compare to the rate of loss?
A) Loss exceeds production
B) Production equals loss
C) They are completely independent
D) Production exceeds loss
  • 43. How long does it take to cross the stratum corneum after reaching the top of the stratum granulosum?
A) About 48 days
B) An additional four weeks
C) About two weeks
D) A few hours
  • 44. What mediates keratinocyte differentiation throughout the epidermis?
A) A protein concentration gradient
B) A temperature gradient
C) A calcium gradient
D) A sodium gradient
  • 45. What is considered a key regulator in the formation of epidermal layers?
A) The calcium gradient
B) The shedding of squamous sheets
C) The rate of cell division
D) The secretion of melanin
  • 46. Where does part of the intracellular calcium increase come from?
A) Keratin filaments
B) Blood plasma proteins
C) Intracellular stores
D) Extracellular melanin
  • 47. What type of receptor is suggested to contribute to the rise in intracellular calcium concentration?
A) Intracellular sodium receptor
B) Extracellular calcium-sensing receptor
C) Light-sensitive photoreceptor
D) Voltage-gated potassium receptor
  • 48. What scientific method is used to quantify skin hydration?
A) Corneometry
B) Biopsy
C) Melanometry
D) Keratometry
  • 49. Where are melanosomes originally formed?
A) Keratinocytes
B) Stratum corneum
C) Melanocytes
D) Merkel cells
  • 50. How do Merkel cells intrinsically transform touch in model organisms like mice?
A) Into chemical gradients
B) Into electrical signals
C) Into lipid barriers
D) Into melanin pigments
  • 51. What is acanthosis?
A) A localized lack of melanocytes
B) Diffuse epidermal hyperplasia
C) Thickening of the stratum corneum only
D) A benign condition simulating squamous cell carcinoma
  • 52. What describes acanthosis nigricans?
A) A black, poorly defined, velvety hyperpigmented acanthosis
B) A localized thickening of the stratum corneum
C) Irregular squamous strands extending down into the dermis
D) Multiple white to pinkish papules in the oral cavity
  • 53. What is another name for focal epithelial hyperplasia?
A) Squamous cell carcinoma
B) Heck's disease
C) Pseudoepitheliomatous hyperplasia
D) Acanthosis nigricans
  • 54. What condition closely simulates squamous cell carcinoma?
A) Heck's disease
B) Diffuse acanthosis
C) Pseudoepitheliomatous hyperplasia
D) Acanthosis nigricans
  • 55. Do the numbers of melanocytes vary between different body regions?
A) No
B) Only after UV exposure
C) Only in white and Asian skin
D) Yes
Created with That Quiz — the site for test creation and grading in math and other subjects.